Our research is centered on three primary domains. First, we focus on the mechanical characterization and functional assessment of biological systems. Second, we investigate mechanics-based platforms for therapeutic applications in disease treatment. Third, we study the molecular and cellular mechanisms underlying aging-related diseases.
A central biological question driving our work is: How do mechanical and biochemical cues within diseased or aberrant microenvironments regulate cellular function, behavior, and signal transduction? Addressing this question requires rigorous quantitative analysis of biophysical phenomena, enabled by advanced 3D multiscale and multimodal imaging systems.
To this end, we are actively developing tissue- and organ-level model systems using state-of-the-art bioprinting technologies. In parallel, we are engineering a suite of tools to quantify drag and traction forces, bond strength, and the mechanical, viscoelastic, and transport properties of molecules, cells, tissues, and biomaterials across multiple scales.
Looking forward, we envision that these integrated quantitative approaches will enable transformative advances in both basic and translational science, ultimately equipping clinicians and clinical scientists with more effective strategies for disease detection and treatment.
